IGF-1 LR3
Long Arg3 Insulin-like Growth Factor-1 — extended half-life IGF-1 analog for hypertrophy, IGF-1 receptor signaling, and tissue growth research
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For research purposes only. Not for human consumption.
Mechanism of Action
IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is an 83-amino acid analog of human IGF-1 with an Arg substitution at position 3 and a 13-amino acid N-terminal extension. These modifications dramatically reduce binding to IGF-binding proteins (IGFBPs), giving it a significantly longer half-life (~20-30 hours) and higher bioactivity than native IGF-1 in research models.
How It Works
- 1
Binds the IGF-1 receptor (IGF-1R) to activate PI3K/Akt and MAPK signaling cascades
- 2
Reduced IGFBP affinity keeps more peptide free and biologically active
- 3
Promotes amino acid uptake and protein synthesis in skeletal muscle models
- 4
Stimulates satellite cell proliferation and myoblast differentiation
- 5
Modulates glucose uptake via cross-talk with the insulin receptor
Key Research Benefits
- Hypertrophy and muscle protein synthesis research
- IGF-1 receptor signaling studies
- Satellite cell and tissue regeneration models
- Extended half-life vs native IGF-1
- Anabolic pathway and growth factor research
IGF-1 LR3's resistance to IGFBP binding makes it a preferred tool for studying sustained IGF-1R activation, hypertrophic signaling, and downstream PI3K/Akt/mTOR pathways in muscle, tendon, and metabolic research.