Kisspeptin
Hypothalamic neuropeptide and master regulator of GnRH for reproductive endocrinology and HPG-axis research.
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For research purposes only. Not for human consumption.
Mechanism of Action
Kisspeptin is a hypothalamic neuropeptide encoded by the KISS1 gene that acts as the master regulator of the reproductive axis by binding the GPR54 (KISS1R) receptor on GnRH neurons, triggering pulsatile gonadotropin-releasing hormone secretion and downstream LH/FSH release.
How It Works
- 1
Activates GPR54 (KISS1R) on hypothalamic GnRH neurons via Gq/PLC signaling, depolarizing the cell and stimulating GnRH release
- 2
Drives pulsatile LH and FSH secretion from the anterior pituitary, supporting endogenous sex steroid production research
- 3
Modulates the HPG axis upstream of GnRH, making it a key probe for puberty onset, fertility, and reproductive aging studies
- 4
Influences metabolic and energy-balance signaling through interactions with leptin and insulin pathways
- 5
Used to investigate hypogonadotropic hypogonadism models and HPG-axis recovery research
Key Research Benefits
- Master regulator of GnRH/LH/FSH research
- HPG-axis upstream signaling probe
- Reproductive endocrinology studies
- Fertility & puberty research models
- Endogenous testosterone pathway investigation
Each vial contains 10mg of lyophilized Kisspeptin-10. Reconstitute with bacteriostatic water and store refrigerated (2–8°C) post-reconstitution; use within 14 days for optimal stability. For research use only — not for human consumption.