PEG-MGF
PEGylated Mechano Growth Factor — extended half-life IGF-1Ec splice variant for satellite cell activation, muscle hypertrophy, and tissue repair research
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For research purposes only. Not for human consumption.
Mechanism of Action
PEG-MGF is a PEGylated form of Mechano Growth Factor (MGF), an IGF-1Ec splice variant expressed in skeletal muscle following mechanical stress. PEGylation extends its systemic half-life by protecting the peptide from rapid proteolysis, allowing sustained satellite cell activation and myogenic signaling.
How It Works
- 1
Activates quiescent satellite cells in skeletal muscle to enter the proliferative pool
- 2
Signals through the IGF-1 receptor axis but with a distinct C-terminal E-domain response
- 3
Drives myoblast fusion and hypertrophic gene expression in damaged muscle tissue
- 4
PEGylation extends plasma half-life from minutes (native MGF) to hours
- 5
Studied alongside IGF-1 LR3 for complementary hypertrophy and repair pathway research
Key Research Benefits
- Satellite cell activation research
- Muscle hypertrophy and repair pathway studies
- IGF-1Ec splice-variant investigation
- Post-exercise recovery models
- Comparative research vs IGF-1 LR3
PEG-MGF requires reconstitution with bacteriostatic water. Each vial contains 2mg of lyophilized peptide. Store refrigerated (2–8°C) post-reconstitution and use within 30 days for optimal stability. For research use only — not for human consumption.