PNC-27
Anticancer peptide for tumor cell research
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For research purposes only. Not for human consumption.
Mechanism of Action
An anticancer peptide containing an HDM-2 binding domain linked to a membrane-active leader sequence that selectively destroys cancer cells expressing surface HDM-2 while leaving healthy cells unharmed.
How It Works
- 1
Identifies cancer cells by binding to HDM-2 protein overexpressed on their surface
- 2
Membrane-penetrating leader sequence embeds into the cancer cell membrane
- 3
Forms pore-like structures that compromise membrane integrity
- 4
Triggers necrotic cell death — healthy cells without surface HDM-2 remain unaffected
Key Research Benefits
- Selective cancer cell targeting
- Healthy cell preservation
- Multiple cancer line efficacy
- Novel mechanism of action
PNC-27 has shown efficacy against multiple cancer cell lines in preclinical studies including pancreatic, breast, and leukemia models. Critical for first responder cancer research due to elevated occupational cancer risks.