SLU-PP-332
ERRα/β/γ pan-agonist exercise mimetic for mitochondrial biogenesis, fatty acid oxidation, and endurance research
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For research purposes only. Not for human consumption.
Mechanism of Action
SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ) — orphan nuclear receptors that act as master regulators of mitochondrial biogenesis, oxidative metabolism, and skeletal muscle endurance. By activating ERRs directly, SLU-PP-332 mimics many of the transcriptional adaptations normally driven by endurance exercise.
How It Works
- 1
Binds and activates all three ERR isoforms (α/β/γ) as a direct agonist
- 2
Upregulates PGC-1α-linked gene programs driving mitochondrial biogenesis
- 3
Increases fatty acid oxidation and oxidative phosphorylation in muscle
- 4
Shifts skeletal muscle toward slow-twitch, fatigue-resistant Type I fibers
- 5
Improves running endurance and metabolic flexibility in preclinical models
- 6
Reduces adiposity and improves glucose handling without altering food intake
Key Research Benefits
- Exercise mimetic pathway research
- Mitochondrial biogenesis studies
- Fatty acid oxidation investigation
- Endurance and muscle fiber-type research
- Obesity and metabolic syndrome models
- Cardiac metabolism and heart failure studies
SLU-PP-332 has been highlighted in published research as a first-in-class ERR pan-agonist that reproduces many transcriptional and phenotypic effects of endurance training in rodent models, including increased running distance, reduced fat mass, and improved insulin sensitivity. For research use only — not for human consumption.